Endocrine Abstracts

We report two ladies who presented with thyroid dysfunction associated with neck swelling. In both cases within ten days of consultation they developed rapid enlargement of their mass associated with marked swelling of an arm.Case 1. A 63 year old lady developed sudden onset of a thyroid swelling associated with a new diagnosis of primary hypothyroidism . She had lost weight and felt tired. On examination she had a moderately enlarged woody goitre, there was no associated ...

Introduction: The prevalence of impaired fasting glucose (IFG) in the elderly approaches 50% in some community-dwelling cohorts. We examined whether IFG is associated with a higher burden of disease, cardiovascular risk factors and circulating low-grade inflammation than in normoglycemic elderly people.Methods/Design: Cross-sectional data of 929 participants of the Sydney Memory and Aging Study (MAS) were examined. MAS is a population-derived cohort of c...

Background: A basic tenet for hormone replacement is to replicate physiology but this is rarely if ever achieved. The adrenal glucocorticoid, cortisol, has a distinct circadian rhythm regulated by the brain’s central pacemaker. Loss of the cortisol circadian rhythm is associated with metabolic abnormalities, depression, fatigue and a poor health-related quality of life. Based on pharmacokinetic modelling we have developed a modified-release hydrocortisone (MR-HC) and test...